Decline of serum albumin precedes severe acute GVHD after haploidentical HSCT

Background: Haploidentical hematopoietic stem cell transplantation (HSCT) is a useful therapy for relapsed/refractory acute leukemia or lymphoma because of the strong graft-vs-leukemia (GVL) effect. However, it often accompanied by severe graft-versus-host disease (aGVHD), which most serious complication after haploidentical HSCT. Thus, important to control severity aGVHD while maintaining GVL In our experience pediatric HSCT, takes several days become appearance initial symptoms, mostly skin rashes. this study, we aimed identify biomarkers at onset that predict subsequent development aGVHD. Methods: Forty-five consecutive children with who developed HSCT were enrolled. We analyzed possible from samples collected GVHD. Results: Nineteen patients grade 1–2 aGVHD, and 26 3–4 There was no significant difference in patient characteristics between two groups. Transplant-related mortality occurred only group (34.5%). Multivariate analysis revealed serum albumin an independent biomarker predicting (P = 0.009). The area under receiver operating characteristic curve 0.864. Conclusions: level aGvHD could be